APC Mouse Anti-Human CD3ε

產品名稱:APC 小鼠抗人 CD3ε 抗體；APC Mouse Anti-Human CD3ε

中文名稱:APC 小鼠抗人 CD3ε 抗體

英文名稱:APC Mouse Anti-Human CD3ε

APC Mouse Anti-Human CD3ε 產品介紹：

Material Number: 558257
Size: 100 tests
Vol. per Test: 20 μl
Clone: APA1/1
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

APC Mouse Anti-Human CD3ε Description：

Monoclonal antibody APA1/1 reacts with the intracellular domain of the epsilon chain of the CD3 molecule (CD3-ε). This antibody does not
react with the extracellular region of CD3-ε. The assembly of the T cell antigen receptor (TCR)-CD3 complex has been suggested to take
place by pairwise interactions of the CD3-ε subunit with either CD3-γ or CD3-δ. These dimers then associate with the TCR heterodimer a/β
or γ/δ, and the CD3-ζ homodimer to form the full complex. Studies show that antibodies APA1/1 and SP34 gave a strong reaction with COS
cells singly transfected with CD3-ε. Other anti-CD3 antibodies (OKT3, WT31, UCHT1, Leu4) did not react with COS cells singly transfected
with CD3-ε. This reagent could be useful for the study of T cell development or the study of conformational changes of CD3-ε upon ligand
binding to TCR-CD3 complex.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.