PE Mouse Anti-Human CD278

產品名稱:PE 小鼠抗人 CD278 抗體；PE Mouse Anti-Human CD278

中文名稱:PE 小鼠抗人 CD278 抗體

英文名稱:PE Mouse Anti-Human CD278

PE Mouse Anti-Human CD278 產品介紹：

Material Number: 557802
Alternate Name: ICOS
Size: 100 tests
Vol. per Test: 20 μl
Clone: DX29
Immunogen: Activated human T cells
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of 
the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and 
also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or 
activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression 
is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an 
important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth 
stimulated by pokeweed mitogen (PWM) and enhanced production of IgG.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.