FITC Perforin Reagent Set

產品名稱:FITC Perforin Reagent Set

FITC Perforin Reagent Set 產品介紹：

Material Number: 556577
Reactivity: QC Testing: Human
Component: 51-65994X
Description: FITC Mouse Anti-Human Perforin
Size: 100 tests (1 ea)
Vol. per Test: 20 μl
Clone Name: δG9
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT
Isotype: Mouse (BALB/c) IgG2b, κ
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Component: 51-66374X-2
Description: FITC Mouse IgG2b κ Isotype Control
Size: 100 tests (1 ea)
Vol. per Test: 20 μl
Clone Name: 27-35
Isotype: Mouse (C.SW) IgG2b, κ
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

FITC Perforin Reagent Set Description：

Perforin has a key role in cell-mediated cytotoxicity. It is a 70 kDa cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic
T lymphocytes (CTLs) and natural killer (NK) cells. CTLs are involved in eliminating virally infected cells, in anti-tumor immune responses,
in allograft rejections, and in some autoimmune diseases. NK cells are important for tumor surveillance and destruction and are involved in
allograft rejections. Cytotoxic cells release the contents of their cytotoxic granules, including perforin upon recognition of their target cell. In
the presence of calcium, perforin forms transmembrane channels or pores in the membrane of the target cell leading to a cell death that
resembles apoptosis. The ability to detect perforin-positive cells with specific antibody should be useful in identifying and understanding
perforin-mediated reactions.

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.

FITC Perforin Reagent Set Suggested Companion Products：

Catalog Number Name Size Clone
554722 Fixation and Permeabilization Solution 125 ml (none)
554723 Perm/Wash Buffer 100 ml (none)