PE Mouse Anti-Human CD195

產品名稱:PE 小鼠抗人 CD195 抗體；PE Mouse Anti-Human CD195

中文名稱:PE 小鼠抗人 CD195 抗體

英文名稱:PE Mouse Anti-Human CD195

PE Mouse Anti-Human CD195 產品介紹：

Material Number: 555993
Alternate Name: CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13
Size: 100 Tests
Vol. per Test: 20 μl
Clone: 2D7/CCR5
Immunogen: Human CCR5 Transfected Cell Line
Isotype: Mouse (C57BL/6) IgG2a, κ
Reactivity: QC Testing: Human
Workshop: VII 70307
Storage Buffer: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09%
sodium azide.

PE Mouse Anti-Human CD195 Description：

The 2D7/CCR5 monoclonal antibody specifically binds to the human chemokine receptor, CCR5. CCR5 is also known as CD195. CCR5 is a
seven transmembrane-spanning G protein-associated molecule. CCR5 belongs to the beta chemokine receptor family. It is expressed on a
subset of T lymphocytes (CD3+CD45RO+CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during
inflammation. It signals a response to at least three chemokines: Regulated upon Activation Normal T-cell Expressed and Secreted
(RANTES), Macrophage Inflammatory Protein-1 (MIP-1) and Monocyte Chemoattractant Protein 2 (MCP-2). Additionally, CCR5 has been
found to be a coreceptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate
that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV
infection. This antibody has been shown to block ligand and gp120 binding. It is also able to neutralize HIV infection.

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.