FITC Mouse Anti-Human CD8

產品名稱:FITC 小鼠抗人 CD8 抗體；FITC Mouse Anti-Human CD8

中文名稱:FITC 小鼠抗人 CD8 抗體

英文名稱:FITC Mouse Anti-Human CD8

FITC Mouse Anti-Human CD8 產品介紹：

Material Number: 555683
Alternate Name: B7-1
Size: 100 tests
Vol. per Test: 20 μl
Clone: BB1
Isotype: Mouse IgM, κ
Reactivity: QC Testing: Human
Workshop: A028, B7.3, BP021
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Reacts with a 60 kD transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Differentiation 
Antigens. There have been several recent studies reporting discrepancies in the expression and function of CD80 when the BB1 clone is used 
compared to other anti-CD80 monoclonals (e.g., L307.4). Caution should therefore be used in the interpretation of data generated using BB1, 
as reports indicate that BB1 may recognize, in addition to CD80, CD74 and even possibly another as yet undefined molecule. CD80, a 
member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules 
expressed on T cells: CD28 and CD152 (CTLA-4). CD80 is also expressed in activated CD4+ and CD8+ T cells, appearing late after 
activation, suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 
molecule by CD28 mAb or by CD80 antigen results in T-cell activation and a signal for IL-2 production.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.