PE Rat Anti-Mouse CD70

產品名稱:PE 大鼠抗小鼠 CD70 抗體；PE Rat Anti-Mouse CD70

中文名稱:PE 大鼠抗小鼠 CD70 抗體

英文名稱:PE Rat Anti-Mouse CD70

PE Rat Anti-Mouse CD70 產品介紹：

Material Number: 555286
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: FR70
Immunogen: BALB/c mouse B lymphoma A20.2J
Isotype: Rat (F344) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



PE Rat Anti-Mouse CD70 Description：

The FR70 antibody reacts with mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily. 
CD70 is the ligand for CD27 and is expressed primarily on activated B cells. CD70 expression can be induced by activation of splenocytes 
with Lipopolysaccharide, anti-IgM, anti-mouse CD40 mAb HM40-3 (Cat. no. 553721) or 3/23 (Cat. no. 553787), or anti-IgM plus 
anti-CD40, but not Concanavalin A or immobilized anti-mouse CD3e mAb 145-2C11 (Cat. no. 553057) plus soluble anti-CD28. IL-4 may 
be a negative regulator of CD70 expression by B cells. Cd70 mRNA is transiently expressed after ConA stimulation of splenocytes or 
thymocytes. CD70 was observed on dendritic cells of mice infected with Leishmania major; however, its level of expression on dendritic cells 
of naive mice was not reported. The CD27-CD70 interaction delivers T-cell1, and NK-cell costimulatory signals. It has been reported that 
FR70 mAb blocks binding of mCD27-Ig fusion protein to mCd70-transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent 
responses. 

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.