Purified Mouse Anti-Human Maspin

產品名稱:Purified 小鼠抗人 Maspin 抗體；Purified Mouse Anti-Human Maspin

中文名稱:Purified 小鼠抗人 Maspin 抗體

英文名稱:Purified Mouse Anti-Human Maspin

Purified Mouse Anti-Human Maspin 產品介紹：

Material Number: 554292
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: G167-70
Immunogen: Recombinant Human Maspin
Isotype: Mouse IgG2b
Reactivity: QC Testing: Human
Target MW: 42 kDa
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide

Purified Mouse Anti-Human Maspin Description：

Maspin is a 42 kDa protein that may play a role in human breast cancer by functioning as a tumor suppressor. Maspin is expressed in normal
mammary epithelial cells, but there is a loss of expression in invasive breast cancer including lymph node and distant metastases. Further,
maspin is not expressed in most mammary carcinoma cell lines. Mammary carcinoma cells transfected with recombinant maspin have a
reduced ability to migrate through reconstituted basement membrane and lose their ability to form tumors in nude mice, providing support for
maspin as a tumor suppressor protein. Maspin has homology to members of the serpin family of protease inhibitors, some of which have been
implicated in the regulation of invasion and metastasis. Yet protease inhibitory activity has not been detected using recombinant maspin. It
has been suggested that maspin, unlike most serpins, may be a ligand-binding serpin rather than a protease inhibitor. However, the question of
whether or not maspin has protease inhibitor activity remains to be determined. G167-70 is specific for human maspin. It detects maspin as a
42 kD protein in western blots of normal human mammary epithelial cells. Many mammary tumor cell lines including MDA-MB-231 (ATCC
HTB 26) and MDA-MB-435S (ATCC HTB 129) lack maspin expression and are suitable as negative controls. Purified recombinant human
maspin from a yeast expression system was used as immunogen.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4°C.