Purified Mouse Anti-Human Androgen Receptor

產品名稱:Purified 小鼠抗人 Androgen Receptor 抗體；Purified Mouse Anti-Human Androgen Receptor

中文名稱:Purified 小鼠抗人 Androgen Receptor 抗體

英文名稱:Purified Mouse Anti-Human Androgen Receptor

Purified Mouse Anti-Human Androgen Receptor 產品介紹：

Material Number: 554224
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: G122-25
Immunogen: Purified human androgen receptor recombinant protein
Isotype: Mouse IgG1
Reactivity: QC Testing: Human
Tested in Development: Rat
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.


Purified Mouse Anti-Human Androgen Receptor Description：

The androgen receptor (AR) mediating androgen effects is a member of the steroid and thyroid hormone receptor gene superfamily encoding
ligand-dependent nuclear transcription factors. They can be divided into three main domains, an N-terminal domain which modulates
transcription efficiency, a central DNA domain which binds to a target gene hormone response element, and a C-terminal hormone binding
domain. Androgens are necessary for normal male development and function. They exert their effects on target tissue through binding to the
AR, followed by association of the AR complex with specific binding sites on DNA. This AR complex may induce or repress gene
transcription. Mutations in the AR gene are associated with androgen insensitivity syndrome, a disorder that causes XY genotypic males to
develop as phenotypic females because of their inability to respond to androgens. AR mutations have also been identified in human prostate
cancer specimens and the LNCaP human prostate cancer cell line. Monoclonal and polyclonal antibodies to the AR have identified
AR-positive cells in a variety of tissues including male and female sexual organs, kidney, liver, adrenal cortex, pituitary gland, skeletal,
cardiac, and smooth muscle cells. The androgen receptor migrates at a molecular weight of ~100 kD in SDS-PAGE. G122-25 recognizes an
epitope localized within the DNA-binding domain (between amino acids 486 and 651) of the human androgen receptor. Additionally,
G122-25 has been shown to recognize androgen receptors in frozen rat prostate tissue sections. G122-25 does not cross-react with estrogen or
progesterone receptors. Purified recombinant human androgen receptor protein was used as immunogen.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4°C.