PE Hamster Anti-Mouse CD154

產品名稱:PE 倉鼠抗小鼠 CD154 抗體；PE Hamster Anti-Mouse CD154

中文名稱:PE 倉鼠抗小鼠 CD154 抗體

英文名稱:PE Hamster Anti-Mouse CD154

PE Hamster Anti-Mouse CD154 產品介紹：

Material Number: 553658
Alternate Name: CD40 Ligand, gp39
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: MR1
Immunogen: Activated mouse Th1 clone D1.6
Isotype: Armenian Hamster IgG3, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

PE Hamster Anti-Mouse CD154 Description：

The MR1 antibody reacts with CD154 (CD40 Ligand, gp39), an accessory molecule expressed on activated T helper (CD4+) lymphocytes.
CD154 has also been detected on other types of leukocytes, including CD8+ T cells, medullary thymocytes, activated CD4+ NK-T cells, and
human NK cells. CD154 plays an important role in costimulatory interactions between T and B lymphocytes and between antigen-presenting
cells and lymphocytes, regulating the immune response at multiple levels. MR1 mAb inhibits in vitro activation of B lymphocytes by T helper
cells by blocking interaction of gp39 with CD40. In vitro interactions of T cells and antigen-presenting cells can also be blocked by the MR1
antibody. In vivo treatment with MR1 antibody blocks the development of experimental autoimmune disease, inhibits formation of germinal
centers and generation of memory B cells, reduces T-lymphocyte responses to allogeneic cells and allografts, prevents intrathymic deletion of
self-reactive T lymphocytes, and disrupts antigen-specific T-cell responses.

PE Hamster Anti-Mouse CD154 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.