PE Rat Anti-Mouse CD11b

產品名稱:PE 大鼠抗小鼠 CD11b 抗體；PE Rat Anti-Mouse CD11b

中文名稱:PE 大鼠抗小鼠 CD11b 抗體

英文名稱:PE Rat Anti-Mouse CD11b

PE Rat Anti-Mouse CD11b 產品介紹：

Material Number: 553311
Alternate Name: CR-3 alpha chain; Itgam; Integrin alpha M; Ly-40; Mac-1 alpha
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: M1/70
Immunogen: Mouse Splenic Cells
Isotype: Rat (DA) IgG2b, κ
Reactivity: QC Testing: Mouse
Reported: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide


PE Rat Anti-Mouse CD11b Description：

The M1/70 antibody reacts with the 170-kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3 
(CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, 
myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after 
activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence 
and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, 
polymorphonuclear leukocytes, and NK cells has been reported. 

PE Rat Anti-Mouse CD11b Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.