APC Rat Anti-Mouse CD31

產品名稱:APC 大鼠抗小鼠 CD31 抗體；APC Rat Anti-Mouse CD31

中文名稱:APC 大鼠抗小鼠 CD31 抗體

英文名稱:APC Rat Anti-Mouse CD31

APC Rat Anti-Mouse CD31 產品介紹：

Material Number: 551262
Alternate Name: PECAM-1
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: MEC 13.3
Immunogen: 129/Sv mouse-derived endothelioma cell line tEnd.1
Isotype: Rat (LEW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa 
integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of ***** and embryonic endothelial cells and is weakly expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the regulation of ligand specificity. CD38 and vitronectin receptor (αvβ3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31. 

APC Rat Anti-Mouse CD31 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.