重組人 HBEGF / DTR 蛋白|HBEGF / DTR Protein|廠家現貨|參數

HBEGF / DTR蛋白產品信息
產品名稱：重組人 HBEGF / DTR 蛋白|HBEGF / DTR Protein|廠家現貨|參數
別名: HBEGF , DTR, DTS, DTSF, HEGFL
表達方式: A DNA sequence encoding the human HBEGF ( Q99075 ) ( Met 1 - Leu 148 ) without the C-terminal propeptide ( aa 149 - 208 ), was expressed and purified
種屬: Human
表達宿主: Baculovirus

HBEGF / DTR蛋白質控指標
純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Asp 63
分子量: The expressed pro form of human HBEGF consists of 148 amino acids and predicts a molecular mass of 16.4 kDa. The processed soluble HBEGF is a 9.7 kDa protein comprising 86 amino acids generated by proteolytic processing
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
HBEGF / DTR蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
HBEGF / DTR蛋白背景綜述
Heparin-binding EGF-like growth factor, also known as HBEGF, Diphtheria toxin receptor and DTR, is a secreted protein which is released into the extracellular space and probably binds to a receptor. Proheparin-binding EGF-like growth factor is a single-pass type I membrane protein. HBEGF contains one EGF-like domain. HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. HBEGF is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. HBEGF also acts as a diphtheria toxin receptor. HBEGF induces trophoblast extravillous differentiation and prevents apoptosis. These functions are compromised in preeclampsia. HBEGF-mediated signaling significantly reduces trophoblast cell death at term and its deficiency in preeclampsia could negatively impact trophoblast survival.
參考文獻
Higashiyama S., et al., 1991, Science 251:936-939.
Mitamura T., et al., 1995, J. Biol. Chem. 270:1015-1019.
Louie G.V., et al., 1997,Mol. Cell 1:67-78.
Imudia,A.N. et al., 2008, Placenta 29 (9):784-9.
Jessmon,P.  et al., 2009, Mol Reprod Dev. 76 (12):1116-27.

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