重組人 EphrinB2 / EFNB2 蛋白|Ephrin-B2 / EFNB2 / LERK-5 Protein|現貨|產品詳情

Ephrin-B2 / EFNB2 / LERK-5蛋白產品信息
產品名稱：重組人 EphrinB2 / EFNB2 蛋白|Ephrin-B2 / EFNB2 / LERK-5 Protein|現貨|產品詳情
別名: EFNB2, RP11-272L14.1, EPLG5, HTKL, Htk-L, LERK5, MGC126226, MGC126227,  MGC126228
表達方式: A DNA sequence encoding the human EFNB2 ( NP_004084.1 ) extracellular domain ( Met 1 - Ala 229 ) was was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
種屬: Human
表達宿主: Human Cells

Ephrin-B2 / EFNB2 / LERK-5蛋白質控指標
純度: > 97 % as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its binding ability in a functional ELISA
Immobilized human EphB4-his at 2 μg/ml ( 100 μl/well ) can bind human EphrinB2 Fc chimera with a linear range of 1 – 25 ng/ml
Immobilized human EphB4 at 2 μg/ml ( 100 μl/well ) can bind human EphrinB2 Fc chimera with a linear range of 1 – 125 ng/ml
內**: < 1.0 EU per μg of the protein as determined by the LAL method.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ile 28
分子量: The recombinant human EFNB2/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 450 amino acids and predicts a molecular mass of 50.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh EFNB2/Fc monomer is approximately 62 kDa due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Ephrin-B2 / EFNB2 / LERK-5蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage.  Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Ephrin-B2 / EFNB2 / LERK-5蛋白背景綜述
The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosyl- phosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The cytoplasmic domains are approximately 80 amino acids long and are highly conserved, especially the last 33 amino acids. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations. Ephrin-B2 is a member of the ephrin ligand family, which binds members of the Eph receptor family. It has been shown to bind EphA4, EphB1, EphB2, EphB3, and EphB4. Ephrin-B2 plays a role in a variety of developmental processes, including arterial-venous differentiation, neural crest cell migration, and axon guidance.
參考文獻
Cerretti, DP. et al., 1995, Mol. Immunol. 32 (16): 1197-205.
Gale, NW. et al.,1996, Neuron.17 (1): 9-19.
Flanagan, J. et al., 1998, Annual Review of Neuroscience. 21: 309-45.
Holder, N. et al., 1999,  Development. 126 (10): 2033-44.
Wilkinson, DG. et al., 2001, Nat. Rev. Neurosci. 2 (3): 155-64.
Murai, KK. et al., 2003, Journal of Cell Science. 116 (Pt 14): 2823-32.

包裝：5g  50ug

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