Ephrin-A5 / EFNA5蛋白產品信息
產品名稱：重組小鼠 EFNA5 / Ephrin-A5 蛋白|Mouse Ephrin-A5 / EFNA5 Protein|參數|產品詳情
別名: AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
表達方式: A DNA sequence encoding the mouse EFNA5 isoform long ( O08543-1 ) without the pro peptide ( Met 1 - Asn 203 ) was expressed, with a polyhistidine tag at the C-terminus
種屬: Mouse
表達宿主: Human Cells
Ephrin-A5 / EFNA5蛋白質控指標
純度: > 97% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 21
分子量: The recombinant mouse EFNA5 consists of 194 amino acids and has a predicted molecular mass of 22.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA5 is approximately 28 kDa due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Ephrin-A5 / EFNA5蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Ephrin-A5 / EFNA5蛋白背景綜述
Mouse ephrin-A5, also known as AL-1, RAGS, or LERK-7 (ligand for eph-related kinases, 7), is a member of the ephrin ligand family which binds the members of Eph receptor subfamily of tyrosine kinases. Based on their structure and sequence relationships, ephrins are divided into ephrin-A and ephrin-B class, and ephrin-A members are anchored to the membrane by GPI linkage. Ephrin-A5 is expressed with the highest levels in human ***** brain, heart, spleen, and ovary and human fetal brain, lung, and kidney. This ligand has been reported to bind Eph A2, Eph A3, Eph A4, Eph A5, Eph A6, Eph A7, Eph A8, and Eph B2 receptors. The interactions between Eph receptors and their ephrin ligands have been implicated in mediating developmental events, particularly in the nervous system through regulating cell migration and axon pathfinding. It has been reported that Ephrin-A5 prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation.
The ephrins (EPH) and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases (RTKs), and have been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class which are anchored to the membrane by a GPI linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. 14 receptors and 8 ligands have been reported in mammals.
參考文獻
Stein, E. et al., 1999, J. Neurosci. 19: 8885-93.
Wilkinson, D.G. 2001, Nat. Rev. Neurosci. 2: 155-164.
Cheng, N. et al., 2002, Cytokine. Growth. Factor. Rev. 13: 75-85.
Himanen, J.P. et al., 2004, Nat. Neurosci. 7: 501-509.
Eberhart, J. et al., 2004, J. Neurosci. 24: 1070-1078.
Irie, F. et al., 2008, Proc. Nat. Acad. Sci. 105: 12307-12.
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