重組人 CD114 / G-CSFR / GCSFR 蛋白|G-CSFR / CD114 Protein|技術資料|廠家

G-CSFR / CD114蛋白產品信息
產品名稱：重組人 CD114 / G-CSFR / GCSFR 蛋白|G-CSFR / CD114 Protein|技術資料|廠家
G-CSFR 別名: CD114, GCSFR, CSF3R
表達方式: A DNA sequence encoding the extracellular domain ( Met 1 - Pro 621 ) of human G-CSF receptor ( NP_000751.1 ) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

G-CSFR / CD114蛋白質控指標
純度: > 95% as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells.
The ED50 for this effect is typically 1-4 ng / ml in the presence of 0.125 ng / mL of recombinant human GCSF
內**: < 1.0 EU per μg of the protein as determined by the LAL method.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 25
分子量: The mature recombinant human G-CSFR/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 835 amino acids and predicts a molecular mass of 93.3 KDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rh GCSFR/Fc monomer is approximately 120-130 KDa due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

G-CSFR / CD114蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

G-CSFR / CD114蛋白背景綜述
Granulocyte Colony Stimulating Factor Receptor (G-CSFR) which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. This type I  membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML).
參考文獻
Fukunaqa, R. et al., EMBO.J. 10: 2855-2865
Dong, F. et al., 1997, Leukemia. 11: 120-125.
Melissa, G. et al., 2000, Blood. 95: 2132-2137.
Germeshausen, M. et al., 2007, Blood. 109: 93-99.

包裝：5ug         50ug 

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