Canine RBP4 Protein|技術資料|廠家價格

RBP4蛋白產品信息

別名: RBP4
表達方式: A DNA sequence encoding the canine RBP4 (F1PQI4) (Met1-Leu201) was expressed with a C-terminal polyhistidine tag.
種屬: Rat
表達宿主: Human Cells

RBP4 Protein QC Testing

純度: >94% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 19
分子量: The recombinant canine RBP4 comprises 194 amino acids and has a predicted molecular mass of 22.4 kDa. The apparent molecular mass of the protein is approximately 23 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

RBP4 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

RBP4蛋白背景綜述

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. In addition, RBP4 is recently identified as an adipokine whose dysregulation is closely associated with the pathogenesis of insulin resistance and type 2 diabetes, as well as obesity.

參考文獻

Colantuoni V. et al., 1983, Nucleic Acid Res. 11: 7769-76.
Loredana Q. et al., 2002, J Biol Chem. 277:30191-7.
Zanotti G. et al., 2004, Vitamins and Hormones. 69: 271-95.
Cho YM. et al., 2006, Diabetes Care. 29: 2457-61.
Balagopal P. et al., 2007, J Clin Endocirnol Metab. 92: 1971-4.

規格：50ug

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