CD1B / CD1A Protein|CD1B / CD1A蛋白質|技術資料|產品詳情

CD1B / CD1A蛋白產品信息

別名: CD1B
表達方式: 
A DNA sequence encoding the human CD1B (NP_001755) (Met1- Ser 303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

CD1B / CD1A Protein QC Testing

純度: >88 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ser 18
分子量: 
The recombinant human CD1B /Fc is a disulfide-linked homodimer. The reduced monomer comprises 527 amino acids and has a predicted molecular mass of 58.6 kDa. The apparent molecular mass of the protein is approximately 59-69 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD1B / CD1A Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD1B / CD1A蛋白背景綜述

CD1A is a member of the CD1 family. CD1 family is composed by transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1A contains 1 Ig-like (immunoglobulin-like) domain and localizes to the plasma membrane and to recycling vesicles of the early endocytic system. As an antigen-presenting protein, CD1A binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. CD1A is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

參考文獻

Coventry B. et al., 2004, Trends Immunol. 25 (5): 242-8.
Martin LH. et al., 1988, Proc Natl Acad Sci. 84 (24): 9189-93.
Aruffo A. et al., 1989, J Immunol. 143 (5): 1723-30.
Longley J. et al., 1989, J Invest Dermatol. 92 (4): 628-31.

規格：50ug

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