Rat CD14 Protein|鼠CD14蛋白質|技術資料|蛋白質

CD14蛋白產品信息

別名: CD14
表達方式: 
A DNA sequence encoding the rat CD14 (Q63691)(Met1-Tyr341) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達宿主: Human Cells

CD14 Protein QC Testing

純度: >93% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ser 18
分子量: 
The recombinant rat CD14/Fc is a disulfide-linked homodimer. The reduced monomer comprises 565 amino acids and has a predicted molecular mass of 62.2 kDa. The apparent molecular mass of the protein is approximately 72 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD14 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD14蛋白背景綜述

CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists as two forms, either anchored into the membrane by a GPI-anchor tail (mCD14) or present as a soluble form (sCD14) in normal serum and body fluids. CD14 was first described as a pattern recognition receptor for lipopolysaccharide (LPS) and a variety of ligands derived from different microbial sources, along with the co-receptors Toll-like receptor TLR 4 and MD-2. The binding of CD14 and LPS depends on the presence and catalytic activity of lipopolysaccharide-binding protein (LBP). Besides its endotoxin signaling function, CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Multiple transcript variants resulting from alternative splicing encode the same isoform of CD14.

參考文獻

Simmons DL. et al., 1989, Blood. 73: 284-9.
Goyert SM. et al., 1988, Science. 239: 497-500.
Heidenreich S. et al., 1999, J Leukoc Biol. 65: 737-43.
Power CP. et al., 2004, J Immunol. 173: 5229-37.
Asea A. et al., 2000, Nat Med. 6: 435-42.

規格：100ug

關 鍵 詞：Rat CD14 Protein,鼠CD14蛋白質,技術資料,蛋白質，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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