MSLN / Mesothelin Protein|MSLN / Mesothelin蛋白質|產品詳情

MSLN / Mesothelin蛋白產品信息

別名: MSLN, MPF
表達方式: 
A DNA sequence encoding the human MSLN (Q13421-2) (Met1-Arg286 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

MSLN / Mesothelin Protein QC Testing

純度: > 99 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Leu 37
分子量: 
The recombinant human MSLN/Fc  comprises 491 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MSLN / Mesothelin Protein Usage Guide

儲存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MSLN / Mesothelin蛋白背景綜述

Megakaryocyte potentiating factor is a member of the mesothelin family. This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Both megakaryocyte potentiating factor and the cleaved form of mesothelin are N-glycosylated. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment. Megakaryocyte potentiating factor interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Its membrane-anchored forms may play a role in cellular adhesion.

參考文獻

Chang MC. et al., 2012, Biochem J. 442 (2): 293-302.
Nelson HH. et al., 2011, Epigenetics. 6 (8): 1029-34.
Bournet B. et al., 2012, Pancreatology. 12 (1): 27-34.

規格：50ug

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