PPIase / FKBP7 Protein|產品詳情|參數

PPIase / FKBP7蛋白產品信息

別名: FKBP7, FKBP23
表達方式: 
A DNA sequence encoding the human FKBP7 (Q9Y680-2)(Met1-Gln218) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

PPIase / FKBP7 Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 24
分子量: 
The recombinant human FKBP7/Fc is a disulfide-linked homodimer. The reduced monomer comprises 436 amino acids and has a predicted molecular mass of 49.4 kDa. The apparent molecular mass of the protein is approximately 55kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PPIase / FKBP7 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PPIase / FKBP7蛋白背景綜述

PPIases contains 1 PPIase cyclophilin-type domain and belongs to the cyclophilin-type PPIase family, PPIL3 subfamily. It also is a member of the immunophilin protein family. Members of this family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. It also may be involved in pre-mRNA splicing.PPIases has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor.

參考文獻

Shor B. et al., 2008, Cancer Res. 68(8):2934-43.
Talmud PJ. et al., 2009, Am J Hum Genet. 2009 Nov;85(5):628-42.
Deleersnijder A. et al., 2011, J Biol Chem. 286(30):26687-701.

規格：50ug

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