SCN3B Protein|SCN3B蛋白質|生產廠家|技術資料

SCN3B蛋白產品信息

別名: SCN3B, KIAA1158
表達方式: 
A DNA sequence encoding the mature form of  human SCN3B (Q9NY72) extracellular domain (Met1-Glu159) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

SCN3B Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Phe 23
分子量: 
The recombinant human SCN3B consists of  148 amino acids and predicts a molecular mass of 17.2 KDa. It migrates as an approximately 29 and 34 kDa due to different glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SCN3B Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SCN3B蛋白背景綜述

SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. SCN3B modulates channel gating kinetics; causes unique persistent sodium currents; inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

參考文獻

Morgan K. et al., 2000, Proc Natl Acad Sci. 97 (5): 2308-13.
Hartley JL. et al. Genome Res. 10 (11): 1788-95.
Hirosawa M. et al., 2000, DNA Res. 6 (5): 329-36.

規格：20ug

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