Rat TNFSF9 Protein|產品詳情|價格

TNFSF9蛋白產品信息

別名: TNFSF9
表達方式: 
A DNA sequence encoding the rat TNFSF9 (Q80WE6) (Pro106-Gly308) was expressed, fused with a polyhistidine tag at the N-terminus.
種屬: Rat
表達宿主: Human Cells

TNFSF9 Protein QC Testing

純度: >88 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: His
分子量: 
The recombinant rat TNFSF9 comprises 223 amino acids and has a predicted molecular mass of 24.8 kDa. The apparent molecular mass of the protein is approximately 35 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFSF9 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFSF9蛋白背景綜述

4-1BB ligand (4-1BBL), also known as TNFSF9, is a member of the tumor necrosis factor (TNF) superfamily (TNFSF), and interacts with 4-1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Mouse 4-1BBL is a 309 amino acid (aa) residues protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that other TNFSF members, but shares only low aa sequence homology (14 - 16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart which is detected in both T and B cells of human peripheral blood. 4-1BB ligand interacts with 4-1BB and co-stimulates the latter to secrete cytokines and to proliferate, and also this interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in colitis without affecting regulatory T cell function.

參考文獻

Goodwin RG. et al., 1993, Eur J Immunol. 23: 2631-41.
Alderson MR. et al., 1994, Eur J Immunol. 24: 2219-27.
Zhou Z. et al., 1995, Immunol Lett. 45 (1-2): 67-73.
Futagawa T. et al., 2002, Int Immunol. 14 (3): 275-86.
Yoshida H. et al., 2003, Cancer Immunol Immunother. 52 (2): 97-106.
Maerten P. et al., 2006, Clin Exp Immunol. 143 (2): 228-36.

規格：20ug

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