Mouse TIGIT / VSTM3 Protein |技術資料|價格

TIGIT/ VSTM3蛋白產品信息

別名: TIGIT, Vstm3
表達方式: A DNA sequence encoding the mouse TIGIT (PP86176) (Met1-Gly141 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Mouse
表達宿主: Human Cells

TIGIT/ VSTM3 Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gly 26
分子量: 
The recombinant mouse TIGIT /Fc is a disulfide-linked homodimer. The reduced monomer comprises 357 amino acids and has a predicted molecular mass of 39.8 kDa. The apparent molecular mass of the protein is approximately 52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TIGIT/ VSTM3 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TIGIT/ VSTM3蛋白背景綜述

TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-10 and diminished the production of IL-12p40. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

參考文獻

Yu X. et al., 2009, Nat Immunol. 10 (1): 48-57.
Stanietsky N. et al., 2009, Proc Natl Acad Sci. 106 (42):17858-63.

規格：50ug

關 鍵 詞：Mouse TIGIT / VSTM3 Protein ,技術資料,價格，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

CANSPEC品質提供的Mouse TIGIT / VSTM3 Protein |技術資料|價格性能**，其優良的品質滿足您不同實驗的多種需求。

本產品由上海創賽品質提供，歡迎咨詢國內免費服務專線：400-608-7598，更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com