Rat ErbB3 / HER3 Protein|鼠ErbB3 / HER3蛋白質|參數|廠家

ErbB3 / HER3蛋白產品信息

別名: ERBB3
表達方式: 
A DNA sequence encoding the rat ERBB3(Q3MHC0)(Met1-His641) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

ErbB3 / HER3 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ser 20
分子量: 
The recombinant rat ERBB3 comprises 633 amino acids and predicts a molecular mass of 69.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 112 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ErbB3 / HER3 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ErbB3 / HER3蛋白背景綜述

ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

參考文獻

Kraus MH. et al., 1989, Proc Natl Acad Sci. 86: 9193-7.
Carraway K.L. et al., 1994, J Biol Chem. 269: 14303-6.
Wallasch C. et al., 1995, EMBO J. 14: 4267-75.
Alimandi M. et al., 1995, Oncogene. 10: 1813-21.
Gamett DC. et al., 1995, J Biol Chem. 270: 19022-7.
Katoh M. et al., 1993, Biochem Biophys Res Commun.192: 1189-97.

規格：50ug

關 鍵 詞：Rat ErbB3 / HER3 Protein|鼠ErbB3 / HER3蛋白質,參數,廠家，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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