Rat CD79B / B29 Protein|產品詳情|價格

CD79B / B29蛋白產品信息

別名: CD79B
表達方式: 
A DNA sequence encoding the rat CD79B(O70153) (Met1-Asp158) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達宿主: Human Cells

CD79B / B29 Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Val 26
分子量: The recombinant rat CD79B/Fc is a disulfide-linked homodimer. The reduced monomer comprises 374 amino acids and has a predicted molecular mass of 42.2 kDa. The apparent molecular mass of the protein is approximately 50 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD79B / B29 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD79B / B29蛋白背景綜述

B-cell antigen receptor complex-associated protein beta chain, also known as B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b and B29, is a single-pass type I membrane protein which contains one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain. CD79b / B29 is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79b / B29 enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b / B29 are the cause of agammaglobulinemia type 6 (AGM6) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

參考文獻

Mueller BS. et al., 1992, Eur J Immunol. 22: 1621-5.
Wood WJ. et al., 1993, Genomics. 16: 187-92.
Hashimoto S. et al., 1994, Immunogenetics. 40: 145-9.
Radaev S. et al., 2010, Structure. 18: 934-43.
Burkard TR. et al., 2011, BMC Syst Biol. 5: 17-17.

規格：20ug

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