Rat Nectin-2 / PVRL2 Protein|技術資料|價格

Nectin-2 / PVRL2蛋白產品信息

別名: PVRL2
表達方式: 
A DNA sequence encoding the rat PVRL2 (Q9ESS6)(Met1-Gly351) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

Nectin-2 / PVRL2 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 32
分子量: 
The recombinant rat PVRL2 comprises 331 amino acids and predicts a molecular mass of 36 kDa. The apparent molecular mass of  the recombinant protein is approximately 46 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Nectin-2 / PVRL2 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Nectin-2 / PVRL2蛋白背景綜述

Poliovirus receptor-related 2 (PVRL2), also known as Nectin-2 and CD112, is a single-pass type I  transmembrane glycoprotein belonging to the nectin family, and structurally comprises two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. Mouse CD112 is a 70 to 78 kDa type I  TM glycoprotein that is found on a variety of cell types. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+T cell-mediated cytotoxicity and cytokine secretion. CD112 protein serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and is involved in cell to cell spreading of these viruses. Disruption of both alleles of the murine CD112 gene resulted in morphologically aberrant spermatozoa. CD112 has also been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy. Mouse CD112 ECD shares 72%, 77%, 95% aa identity with the ECD in human, canine and rat CD112, respectively.

參考文獻

Lopez M. et al., 1998, Blood. 92: 4602-11.
Cocchi F. et al., 2000, J Virol. 74: 3909-17.
Peng YF. et al., 2002, Oncogene. 21: 4108-19.
Tahara HS. et al., 2005, Biochem Biophys Res Commun. 329: 996-1000.
Bachelet I. et al., 2006, J Biol Chem. 281: 27190-6.
Wang, L. et al., 2009, Vet Immunol Immunopathol.

規格：50ug

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