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    產品資料

    Cynomolgus CD38 Protein|產品詳情|技術資料

    產品名稱: Cynomolgus CD38 Protein|產品詳情|技術資料
    產品型號: C86-900-50
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Cynomolgus CD38 Protein|產品詳情|技術資料由上海創賽科學儀器有限公司品質提供,可查詢Cynomolgus CD38 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Cynomolgus CD38 Protein|產品詳情|技術資料  的詳細介紹

    CD38蛋白產品信息

    別名: CD38
    表達方式: 
    A DNA sequence encoding the cynomolgus CD38 (Q5VAN0) (Leu44-Ile301) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
    種屬: Cynomolgus
    表達宿主: Human Cells

    CD38 Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Leu 44
    分子量: 
    The recombinant cynomolgus CD38 is a disulfide-linked homodimer. The reduced monomer comprises 499 amino acids and has a calculated molecular mass of 56.9 KDa.The apparent molecular mass of cynomolgus CD38  is approximately 68 KDa respectively in SDS-PAGE.
    緩沖液: Lyophilized from sterile PBS, pH7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CD38 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CD38蛋白背景綜述

    CD38, also known as ADP-ribosyl cyclase, is a transmembrane glycoprotein comprising two to four N-linked oligosaccharide chains containing sialic acid residues. It is expressed on the surface of immune cells including CD4+, CD8+, B and natural killer cells. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. CD38 functions in cell adhesion, signal transduction and calcium signaling. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic β cells. CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and has been connected to human immunodeficiency virus (HIV) infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism, as well as some genetically determined conditions. In addition, it was demonstrated that CD38 not only acts as a key modulator of the immune response, but also plays an equally important role as an intrinsic pulmonary component. CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions.

    參考文獻

    Deaglio S. et al., 2001, Leuk Res. 25 (1): 1-12.
    Jin D. et al., 2007, Nature. 446 (7131): 41-5.
    Orciani M. et al., 2008, J Cell Biochem. 105 (3): 905-12.
    Malavasi F. et al., 2008, Physiol Rev. 88 (3): 841-86.
    Chini EN. et al., 2009, Curr Pharm Des. 15 (1): 57-63.

    規格:10ug

    關 鍵 詞:Cynomolgus CD38 Protein,產品詳情,技術資料,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Cynomolgus CD38 Protein|產品詳情|技術資料性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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