TMED1 Protein|TMED1蛋白質|產品詳情|價格

TMED1蛋白產品信息

別名: TMED1, IL1RL1L, IL1RL1LG
表達方式: 
A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

TMED1 Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 24
分子量: 
The recombinant human TMED1 consists of  182 amino acids and predicts a molecular mass of 20.6 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TMED1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TMED1蛋白背景綜述

TMED1 is a member of the EMP24/GP25L family. It is widely expressed and contains 1 GOLD domain. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS.

參考文獻

Colland F. et al., 2004, Genome Res. 14 (7): 1324-32.
Gerhard DS. et al., 2005, Nature. 437 (7062): 1173-8.
Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.

規格：20ug

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