Mouse EDA2R / TNFRSF27 Protein|技術資料|廠家現貨

EDA2R / TNFRSF27蛋白產品信息

別名: EDA2R,Tnfrsf27, Xedar
表達方式: 
A DNA sequence encoding the mouse EDA2R (Q8BX35)(Met1-Thr138) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Mouse
表達宿主: Human Cells
EDA2R / TNFRSF27 Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE:

EDA2R / TNFRSF27 protein
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: 
The recombinant mouse EDA2R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 379 amino acids and has a predicted molecular mass of 42.4 kDa. The apparent molecular mass of the protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
EDA2R / TNFRSF27 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EDA2R / TNFRSF27蛋白背景綜述

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

參考文獻

Yan M. et al., 2000,Science. 290: 523-7.
Sinha SK. et al., 2002, J Biol Chem. 277: 44953-61.
Prodi DA. et al., 2008, J Invest Dermatol. 128 (9): 2268-70.

規格：50ug

關 鍵 詞：Mouse EDA2R / TNFRSF27 Protein,技術資料,廠家現貨，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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