Mouse SHP2 / PTPN11 Protein|產品詳情|現貨

SHP2 / PTPN11蛋白產品信息

別名: PTPN11
表達方式: 
A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.
種屬: Mouse
表達宿主: Human Cells

SHP2 / PTPN11 Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: 
The recombinant mouse PTPN11 comprises 604 amino acids and has a predicted molecular mass of 69.5 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SHP2 / PTPN11 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SHP2 / PTPN11蛋白背景綜述

SHP2, also known as PTPN11, is a member of the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. It contains 2 SH2 domains and 1 tyrosine-protein phosphatase domain. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

參考文獻

Ganju R K et al., 2000, J Biol Chem. 275 (23): 17263-8.
Yin T et al., 1997, J Biol Chem. 272 (2): 1032-7.
Kontaridis MI et al., 2006, J Biol Chem. 281 (10): 6785-92.

規格：100ug

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