IL23R / IL23 Receptor Protein|技術資料|價格|廠家

IL23R / IL23 Receptor蛋白產品信息

別名: IL23R
表達方式: 
A DNA sequence encoding the human IL23R (Met1-Asp353) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

IL23R / IL23 Receptor Protein QC Testing

純度: (45+17.3+30.1) % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gly 24
分子量: 
The recombinant human IL23R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a predicted molecular mass of 64.9 kDa. The apparent molecular mass of the protein is approximately 92, 58 and 37 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL23R / IL23 Receptor Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL23R / IL23 Receptor蛋白背景綜述

IL23R, also known as IL23Receptor, is a member of the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

參考文獻

Duerr RH. et al., 2006, Science. 314 (5804): 1461-3.
Cargill M. et al., 2007, Am J Hum Genet. 80 (2): 273-90.
Dubinsky MC. et al., 2007, Inflamm Bowel Dis. 13 (5): 511-5.
Tremelling M. et al., 2007, Gastroenterology. 132 (5): 1657-64.

規格：50ug

關 鍵 詞：IL23R / IL23 Receptor Protein,技術資料,價格,廠家，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

CANSPEC品質提供的IL23R / IL23 Receptor Protein|技術資料|價格|廠家性能**，其優良的品質滿足您不同實驗的多種需求。

本產品由上海創賽品質提供，歡迎咨詢國內免費服務專線：400-608-7598，更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com