Rat ICOS / AILIM Protein |產品詳情|價格

ICOS/ AILIM蛋白產品信息

別名: ICOS, Ailim
表達方式: 
A DNA sequence encoding the rat ICOS (Q9R1T7-1) (Met1-Leu142) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達宿主: Human Cells

ICOS/ AILIM Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 21
分子量: 
The recombinant rat ICOS /Fc is a disulfide-linked homodimer. The reduced monomer comprises 363 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ICOS/ AILIM Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ICOS/ AILIM蛋白背景綜述

Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. Optimal T cell activation and expansion are regulated by signals delivered not only through the T cell receptor (TCR), but also a number of costimulatory molecules. ICOS is expressed on antigen-primed T cells, and B7RP-1(or B7-H2) on B cells and macrophages has been identified as the ICOS ligand. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T-B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS also regulates TH2-mediated mucosal inflammatory responses partially through the signal for up-regulation of the chemokine receptors, and accordingly, aberrant expression of ICOS is implicated in allergic inflammatory responses and other immunity disorders.

參考文獻

Hutloff A. et al., 1999, Nature. 397: 263-6.
Yoshinaga SK. et al. 1999, Nature. 402: 827-32.
Gonzalo JA. et al., 2001, Nat Immunol. 2: 597-604.
Coyle A.J. et al., 2000, Immunity. 13: 95-105.
Dong C. et al. 2001, Nature. 409: 97-101.
Aicher A. et al., 2000, J Immunol. 164: 4689-96.

規格：50ug

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