Cynomolgus TNFRSF10D Protein|價格|廠家|實驗說明

TNFRSF10D蛋白產品信息

別名: TNFRSF10D
表達方式: 
A DNA sequence encoding the cynomolgus TNFRSF10D (F6TP11) (Met1-Leu206) was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

TNFRSF10D Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 56
分子量: 
The recombinant cynomolgus TNFRSF10D comprises 162 amino acids and has a calculated molecular mass of 17.3 KDa. The apparent molecular mass of it is approximately 52-57 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF10D Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF10D蛋白背景綜述

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, are TNF superfamily members, and preferentially induces apoptosis in tumor cell lines, but not in normal cells. TRAIL binds at least five different receptors with characteristic cysteine-rich repeats. Human TRAILR4, also known as decoy receptor 2 (DcR2) and TRUNND (TRAIL receptor with a truncated death domain), is a member of the TNF receptor superfamily and is referred to as TNFRSF10D. TRAILR4 shows a unique expression pattern in human tissues and is particularly abundant in fetal liver and ***** testis. This protein is a type 1 transmembrane receptor consisting of an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. Accordingly, TRAILR4 is not capable of activating TRAIL-mediated NF-kappaB or apoptosis pathways, and identified as an antiapoptotic receptor, although it retains one third of a consensus death domain motif in its cytoplasmic domain. It has been demonstrated that TRAILR4 expression is directly regulated by p53 and attenuates cell response to DNA-damaging agents.

參考文獻

Degli-Esposti MA. et al., 1997, Immunity. 7: 813-20.
Pan G. et al., 1998, FEBS Lett. 424: 41-5.
Shivapurkar N. et al., 2004, Int J Cancer. 109: 786-92.
Liu X. et al., 2005, Cancer Res. 65: 9169-75.
Baetu TM. et al., J. 2002, Cytokine Growth Factor Rev.13: 199-207.

規格：100ug

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