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    產品資料

    Rat CD226 / DNAM-1 Protein|技術資料|現貨

    產品名稱: Rat CD226 / DNAM-1 Protein|技術資料|現貨
    產品型號: C86-803-69
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Rat CD226 / DNAM-1 Protein|技術資料|現貨由上海創賽科學儀器有限公司品質提供,可查詢Rat CD226 / DNAM-1 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Rat CD226 / DNAM-1 Protein|技術資料|現貨  的詳細介紹

    CD226 / DNAM-1蛋白產品信息

    別名: CD226
    表達方式: 
    A DNA sequence encoding the rat CD226 (D3ZS97) (Met1-Ile265) was expressed with the Fc region of human IgG1 at the C-terminus.
    種屬: Rat
    表達宿主: Human Cells

    CD226 / DNAM-1 Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Glu 32
    分子量: 
    The recombinant rat CD226/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a predicted molecular mass of 53.6 kDa. The apparent molecular mass of the protein is approximately 62-68 kDa in SDS-PAGE under reducing conditions.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CD226 / DNAM-1 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CD226 / DNAM-1蛋白背景綜述

    The leukocyte adhesion molecule DNAM1, also known as CD226, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. DNAM1 is identified as an intercellular adhesion molecule which are constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR or CD155) and its family member nectin 2 (CD112) have been identified as the ligands for DNAM1. Interaction of DNAM1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. DNAM1 also plays an important role in immune surveillance of tumor development and is involved in triggering naive T cell differentiation and proliferation. Similarly, murine DNAM1 and PVR homologues physically and functionally bind each other in vivo, and ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. Within the ECD, mouse DNAM1 shares 52% and 86% aa sequence identity with human and rat DNAM1, respectively.

    參考文獻

    Shibuya A. et al., 1996, Immunity. 4 (6): 573-81.
    Shibuya K. et al., 2003, J Exp Med. 198 (12): 1829-39.
    Tahara HS. et al., 2005, Biochem Biophys Res Commun. 329 (3): 996-1000.
    Iguchi-Manaka A. et al., 2008, J Exp Med. 205 (13): 2959-64.

    規格:50ug

    關 鍵 詞:Rat CD226 / DNAM-1 Protein,技術資料,現貨,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Rat CD226 / DNAM-1 Protein|技術資料|現貨性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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