MBD2 / DPEP2 Protein|MBD2 / DPEP2蛋白質|現貨|價格

MBD2 / DPEP2蛋白產品信息

別名: DPEP2
表達方式: 
A DNA sequence encoding the human DPEP2 (AAH24021.1)(Met1-Ser376) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

MBD2 / DPEP2 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 33
分子量: 
The recombinant human DPEP2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 585 amino acids and has a predicted molecular mass of 65 kDa. The apparent molecular mass of the protein is approximately 43-49 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MBD2 / DPEP2 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MBD2 / DPEP2蛋白背景綜述

MBD2, also known as DPEP2, is a nuclear protein. It belongs to a family related by the presence in each of a methyl-CpG-binding domain (MBD). Besides MBD2, the family members also include MECP2, MBD1, MBD3, and MBD4. Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. It is reported that MBD2 functions as a demethylase. MBD2 may function as a mediator of the biological consequences of the methylation signal.

參考文獻

Hendrich B. et al., 1999, Mamm Genome. 10 (9): 906-12.
Brackertz. et al., 2002, J Biol Chem. 277 (43): 40958-66.
Zhang Y. et al., 1999, Nat Genet. 23 (1): 58-61.

規格：20ug

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