FKBP14 Protein|FKBP14蛋白質|廠家現貨|產品詳情

FKBP14蛋白產品信息

別名: FKBP14, FKBP22
表達方式: 
A DNA sequence encoding the human FKBP14 (Q9NWM8) (Met1-Lys207) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

FKBP14 Protein QC Testing

純度: (73.1+25.2) % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 20
分子量: 
The recombinant human FKBP14 consists of  199 amino acids and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 and 27 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FKBP14 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FKBP14蛋白背景綜述

FKBP14 is a member of the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.

參考文獻

Baker K. et al., 2003, Genome Res. 13: 2265-70.
Ota T. et al., 2004, Nat Genet. 36: 40-5.
The MGC Project Team. 2004, Genome Res. 14: 2121-7.

規格：50ug

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