Cynomolgus SELL / Selectin L / L-selectin Protein|產品詳情|價格

SELL / Selectin L / L-selectin蛋白產品信息

別名: SELL
表達方式: 
A DNA sequence encoding the cynomolgus SELL (Q95198) (Met1-Asn332) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

SELL / Selectin L / L-selectin Protein QC Testing

純度: (70.4+19.8)% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Asp 29
分子量: 
The recombinant cynomolgus SELL is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a calculated molecular mass of 61.1 KDa. The apparent molecular mass of the protein is approximately 85 and 35 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SELL / Selectin L / L-selectin Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SELL / Selectin L / L-selectin蛋白背景綜述

L-selectin ( SELL ), also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups and are involved in the regulation of leukocyte traffic. Selectins are composed of an N-terminal C-type lectin domain, a single EGF domain, a variable number of short consensus repeat (SCR) domains, a transmembrane region and a cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin is commonly found on the cell surfaces of  T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs.

參考文獻

Kansas GS. 1992, APMIS. 100 (4): 287-93.
Stamenkovic I. 1995, Curr Opin Hematol. 2 (1): 68-75.
Brenner B. et al., 1997, Proc Natl Acad Sci. 93 (26): 15376-81.

規格：100ug

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