Cynomolgus PDCD1LG2 / B7-DC / PD-L2 Protein|價格|產品詳情|參數

PDCD1LG2 / B7-DC / PD-L2蛋白產品信息

別名: PDCD1LG2
表達方式: 
A DNA sequence encoding the cynomolgus PDCD1LG2(A4GW30) (Met1-Pro219) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

PDCD1LG2 / B7-DC / PD-L2 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Leu 20
分子量: 
The recombinant cynomolgus PDCD1LG2 is a disulfide-linked homodimer. The reduced monomer comprises 441 amino acids and has a calculated molecular mass of 49.6 KDa. The apparent molecular mass of the protein is approximately 66 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PDCD1LG2 / B7-DC / PD-L2 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PDCD1LG2 / B7-DC / PD-L2蛋白背景綜述

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is the ligands for programmed death-1 (PD-1), which is a member of the CD28/B7 family and has been implicated in peripheral tolerance. CD28/B7 signals have been shown to have the capacity to regulate T cell activation and participate in regulating the development of rheumatoid arthritis (RA). B7-DC fails to bind the B7-1/2 receptors CD28 and cytotoxic T lymphocyte–associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T cell proliferation more efficiently than B7-1 and induces a distinct pattern of lymphokine secretion. In particular, B7-DC strongly costimulates interferon γ but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. On the cellular level, all of them were found on cell membrane and in cytoplasma. The expression of B7-DC and B7-H3 was major on capillaries, synovicytes and infiltrated inflammatory cells in the lining layer, from RA patients. B7-DC expression was scarcely expressed on dendritic cells in naive mice, but was up-regulated after allergen challenge, although the up-regulation of B7-DC expression on macrophages was minimal.

參考文獻

Greenwald RJ. et al., 2005, Annu Rev Immunol. 23: 515-48.
Matsumoto K. et al., 2004, The Journal of Immunology. 172: 2530-41.
Tseng SY. et al., 2001, JEM. 193 (7): 839-46.

規格：100ug

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