Mouse Biglycan / PG-S1 / BGN Protein|廠家現貨|產品詳情

Biglycan / PG-S1 / BGN蛋白產品信息

別名: BGN
表達方式: 
A DNA sequence encoding the mouse BGN (Met1-Lys369) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Mouse
表達宿主: Human Cells

Biglycan / PG-S1 / BGN Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 20
分子量: 
The recombinant mouse BGN /Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 amino acids and has a predicted molecular mass of 66.5 KDa. The apparent molecular mass of the protein is approximately 67 KDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Biglycan / PG-S1 / BGN Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Biglycan / PG-S1 / BGN蛋白背景綜述

Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

參考文獻

Harrach B. et al., 1995, The Journal of Biological Chemistry. 270 (6): 2776-83.
Young MF. et al., 1989, The Journal of Biological Chemistry. 264 (8): 4571-6.
Liu J. et al., 1993, The Biochemical Journal. 295 (2): 421-6.
White RJ. et al., 1989, The Biochemical Journal. 262 (3): 823-7.

規格：50ug

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