Mouse PGF / PIGF / PLGF Protein|價格|產品詳情

PGF / PIGF / PLGF蛋白產品信息

別名: PGF, Plgf
表達方式: 
A DNA sequence encoding the mouse PGF (P49764) (Met1-Pro158) was fused with five amino acids (DDDDK) at the C- terminus was expressed and purified.
種屬: Mouse
表達宿主: Human Cells

PGF / PIGF / PLGF Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Val 19
分子量: 
The recombinant mouse PGF consists of 146 amino acids and has a calculated molecular mass of 16.6 kDa. The recombinant protein migrates as an approximately 28 kDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PGF / PIGF / PLGF Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PGF / PIGF / PLGF蛋白背景綜述

Placental growth factor (PlGF, PLGF, PGF), and its receptor VEGFR-1 (Flt-1) constitute potential candidates for therapeutic modulation of angiogenesis and inflammation. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF/PLGF is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides inducing its own signaling in endothelial cells, PlGF exerts its angiogenic action by synergising with VEGF. In the skin, PlGF expression is upregulated during wound healing and PlGF-deficient mice show delayed wound closure, indicating that this factor promotes angiogenesis during skin repair. Moreover, PlGF expression by melanoma cells has been linked to tumor growth.

參考文獻

Khalil A. et al., 2008, PLoS ONE. 3 (7): e2766.
Luttun A. 2002, Ann N Y Acad Sci. 979: 80-93.
Chaballe L. et al., 2011, Acta Neurol Belg. 111 (1): 10-7.
Odorisio T. et al., 2006, J Dermatol Sci. 41 (1): 11-9.

規格：200ug

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