CD36 / GP3B蛋白產品信息
別名: CD36
表達方式: A DNA sequence encoding the cynomolgus CD36 (Q6J512) (Gly30-Asn439) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells
CD36 / GP3B Protein QC Testing
純度: > 70 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gly 30
分子量:
The recombinant cynomolgus CD36 is a disulfide-linked homodimer. The reduced monomer comprises 651 amino acids and has a calculated molecular mass of 73.6 KDa. The apparent molecular mass of the protein is approximately 106 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD36 / GP3B Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD36 / GP3B蛋白背景綜述
Platelet glycoprotein 4, also known as Leukocyte differentiation antigen CD36, GPIIIB, GP3B, FAT, and CD36, is integral membrane protein found on the surface of many cell types in vertebrate animals. It belongs to the CD36 family and is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 has also been implicated in hemostasis, thrombosis, malaria, inflammation, lipid metabolism and atherogenesis. CD36 seems to have numerous potential physiological functions. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of plasmodium falciparum parasitized erythrocytes and binds long chain fatty acids. CD36 may also function as a cell adhesion molecule and in the transport and/or as a regulator of fatty acid transport. Defects in CD36 are the cause of platelet glycoprotein IV deficiency also known as CD36 deficiency. As a receptor for thrombospondin 1, CD36 plays a role in the regulation of angiogenesis, which may be a therapeutic strategy for controlling the dissemination of malignant neoplasms.
參考文獻
Oquendo P. et al., 1989, Cell. 58 (1): 95-101.
Tandon NN. et al., 1989, J Biol Chem. 264 (13): 7576-83.
Silverstein RL. et al., 1992, J Biol Chem. 267 (23): 16607-12.
Ge Y. et al., 2005, Lab Hematol. 11 (1): 31-7.
規格：50ug
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