Rat EPHA7 / EHK3 Protein|產品詳情|價格

EPHA7 / EHK3蛋白產品信息

別名: EPHA7, Ehk-3, Ehk3
表達方式: 
A DNA sequence encoding the rat EPHA7 (Met1-Ser539) was expressed with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

EPHA7 / EHK3 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 28
分子量: 
The recombinant rat EPHA7 comprises 523 amino acids and predicts a molecular mass of 58.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 59 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EPHA7 / EHK3 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EPHA7 / EHK3蛋白背景綜述

Ephrin type-A receptor 7, also known as EPH homology kinase 3, EPH-like kinase 11, EPHA7 and EHK3, is a single-pass type I membrane protein which Belongs to the protein kinase superfamily, Tyr protein kinase family and Ephrin receptor subfamily. EPHA7 is widely expressed. It contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA7 is a receptor for members of the ephrin-A family. It binds to ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4 and ephrin-A5. EPHA7 is a member of the EPHA family of receptor kinases, among which several members are known to be involved in human lung carcinogenesis. EPHA7 is expressed at a substantial level in most human lung cancers and the secreted form of EPHA7 mRNA was found in a fraction of primary lung cancer tissues, lung cancer cell lines, and immortalized bronchogenic epithelial cell lines. The high expression of EphA7 protein may play an important role in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma. EPHA7 warrants further investigation to determine its possible involvement in smoking related lung carcinogenesis.

參考文獻

Wang J. et al., 2005, Oncogene. 24 (36): 5637-47.
García-Calero E. et al., 2006, Neuroscience. 141 (4): 1887-97.
Figueroa JD. et al., 2006, Neurosci Res. 84 (7): 1438-51.
Wang J. et al., 2007, Hum Pathol. 38 (11): 1649-56.
Tsuboi M. et al., 2010, Int J Oncol. 36 (3): 635-40.

規格：200ug

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