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    產品資料

    Rat CD10 / MME / Neprilysin Protein|技術資料|價格

    產品名稱: Rat CD10 / MME / Neprilysin Protein|技術資料|價格
    產品型號: C86-802-88
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Rat CD10 / MME / Neprilysin Protein|技術資料|價格由上海創賽科學儀器有限公司品質提供,可查詢Rat CD10 / MME / Neprilysin Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Rat CD10 / MME / Neprilysin Protein|技術資料|價格  的詳細介紹

    CD10 / MME / Neprilysin蛋白產品信息

    別名: MME
    表達方式: 
    A DNA sequence encoding the rat MME (P07861) (Tyr52-Trp750) was expressed with a polyhistidine tag at the N-terminus.
    種屬: Rat
    表達宿主: Human Cells

    CD10 / MME / Neprilysin Protein QC Testing

    純度: >95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: His
    分子量: 
    The recombinant rat MME comprises 719 amino acids and has a predicted molecular mass of 82.5 kDa. The apparent molecular mass of the protein is approximately 93 kDa in SDS-PAGE under reducing conditions.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CD10 / MME / Neprilysin Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CD10 / MME / Neprilysin蛋白背景綜述

    Neprilysin, also known as neutral endopeptidase ( NEP ) and MME, is a type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. Neprilysin is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer‘s disease (AD). MME is also identified as the common acute lymphoblastic leukemia antigen ( CALLA ) or CD10 present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL). In addition, associations have been observed between neprilysin expression and various types of cancer, and in some cancer models NEP is demonstrated to negatively regulate angiogenesis through proteolytically inactivating the fibroblast growth factor-2 ( FGF-2 ). Accordingly, Loss or a decrease in neprilysin expression has been reported in a several malignancies, as well as Alzheimer's-like behavioral impairment and amyloid-beta deposition in the brain.

    參考文獻

    Shipp MA. et al. 1989, Proc Natl Acad Sci. 86: 297-301.
    Goodman OB. et al., 2006, J Biol Chem. 281: 33597-605.
    Cohen AJ. 1996, Cancer Res. 56: 831-9.
    Iwata N. et al., 2001, Science. 292: 1550-2.
    EI-Amouri SS. et al., 2008, Am J Pathol. 172: 1342-54.

    規格:10ug

    關 鍵 詞:Rat CD10 / MME / Neprilysin Protein,技術資料,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Rat CD10 / MME / Neprilysin Protein|技術資料|價格性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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