SIRPG蛋白產品信息
別名: SIRPG
表達方式:
A DNA sequence encoding the cynomolgus SIRPG (Met1-His360) was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells
SIRPG Protein QC Testing
純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 29
分子量:
The recombinant heterodimer of cynomolgus SIRPG comprises 343amino acids and has a calculated molecular mass of 38.1 KDa. The apparent molecular mass of the protein is approximately 45 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
SIRPG Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SIRPG蛋白背景綜述
Signal-regulatory protein gamma, also known as SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-beta-2, CD172g and SIRPG, is a single-pass type I membrane protein. SIRPG / CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. It is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG / CD172g contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG / CD172g is primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection. SIRPG / CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, it mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
參考文獻
Ichigotani Y. et al., 2000, J Hum Genet. 45: 378-82.
Van den Berg TK. et al., 2005, J Immunol. 175 (12): 7788-9.
Piccio L. et al., 2005, Blood. 105: 2421-7.
Hatherley D. et al., 2008, Mol Cell. 31: 266-77.
規格：50ug
關 鍵 詞：Cynomolgus SIRPG Protein,廠家現貨,價格，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家
CANSPEC品質提供的Cynomolgus SIRPG Protein|廠家現貨|價格性能**，其優良的品質滿足您不同實驗的多種需求。
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