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    產品資料

    Cynomolgus SIRPG Protein|廠家現貨|價格

    產品名稱: Cynomolgus SIRPG Protein|廠家現貨|價格
    產品型號: C86-902-26
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Cynomolgus SIRPG Protein|廠家現貨|價格由上海創賽科學儀器有限公司品質提供,可查詢Cynomolgus SIRPG Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Cynomolgus SIRPG Protein|廠家現貨|價格  的詳細介紹

    SIRPG蛋白產品信息

    別名: SIRPG
    表達方式: 
    A DNA sequence encoding the cynomolgus SIRPG (Met1-His360) was expressed with a polyhistidine tag at the C-terminus.
    種屬: Cynomolgus
    表達宿主: Human Cells

    SIRPG Protein QC Testing

    純度: > 90 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Glu 29
    分子量: 
    The recombinant heterodimer of cynomolgus SIRPG comprises 343amino acids and has a calculated molecular mass of 38.1 KDa. The apparent molecular mass of the protein is approximately 45 KDa respectively in SDS-PAGE.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    SIRPG Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    SIRPG蛋白背景綜述

    Signal-regulatory protein gamma, also known as SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-beta-2, CD172g and SIRPG, is a single-pass type I  membrane protein. SIRPG / CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. It is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG / CD172g contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG / CD172g is primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection. SIRPG / CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, it mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

    參考文獻

    Ichigotani Y. et al., 2000, J Hum Genet. 45: 378-82.
    Van den Berg TK. et al., 2005, J Immunol. 175 (12): 7788-9.
    Piccio L. et al., 2005, Blood. 105: 2421-7.
    Hatherley D. et al., 2008, Mol Cell. 31: 266-77.

    規格:50ug

    關 鍵 詞:Cynomolgus SIRPG Protein,廠家現貨,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

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