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    產品資料

    Cynomolgus CTLA4 / CD152 Protein|技術資料|現貨

    產品名稱: Cynomolgus CTLA4 / CD152 Protein|技術資料|現貨
    產品型號: C86-902-13
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Cynomolgus CTLA4 / CD152 Protein|技術資料|現貨由上海創賽科學儀器有限公司品質提供,可查詢Cynomolgus CTLA4 / CD152 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Cynomolgus CTLA4 / CD152 Protein|技術資料|現貨  的詳細介紹

    CTLA4 / CD152蛋白產品信息

    別名: CTLA4, CTLA-4
    表達方式: 
    A DNA sequence encoding the cynomolgus CTLA4 (Q9BDC4) (Met1-Asp161) was expressed with a polyhistidine tag at the C-terminus.
    種屬: Cynomolgus
    表達宿主: Human Cells

    CTLA4 / CD152 Protein QC Testing

    純度: (73.4+23.7)% as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Ala 37
    分子量: 
    The recombinant cynomolgus CTLA4 comprises 136 amino acids and has a calculated molecular mass of 14.9 KDa. The apparent molecular mass of it is approximately 24 and 21 KDa respectively in SDS-PAGE.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CTLA4 / CD152 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CTLA4 / CD152蛋白背景綜述

    Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is widely expressed with highest levels in lymphoid tissues. CTLA4 contains a extracellular V domain, a transmembrane domain, and a cytoplasmic?tail. Alternate splice variants encoding different isoforms have been characterized. CTLA4 is similar to the T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus (SLE), Graves disease (GRD), Celiac disease type 3 (CELIAC3) and Hepatitis B virus infection (HBV infection).

    參考文獻

    Dariavach P. et al.,1988, Eur J Immunol. 18 (12): 1901-5.
    Waterhouse P. et al., 1995. Science. 270 (5238): 985-8.
    Magistrelli G. et al.,1999, Eur J Immunol. 29 (11): 3596-602.
    Schneider H. et al., 2006, Science. 313 (5795): 1972-5.
    Rudd CE. et al., 2009, Immunol Rev. 229 (1): 12-26.

    規格:100ug

    關 鍵 詞:Cynomolgus CTLA4 / CD152 Protein,技術資料,現貨,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Cynomolgus CTLA4 / CD152 Protein|技術資料|現貨性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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