TPM4 / Tropomyosin 4蛋白產品信息
別名: TPM4 表達方式: A DNA sequence encoding the human TPM4 (P67936) (Ala2-Ile248) was expressed with an N-terminal polyhistidine tag. 種屬: Human 表達宿主: Human Cells TPM4 / Tropomyosin 4 Protein QC Testing
純度: > 95 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: His 分子量: The recombinant human TPM4 comprises 267 amino acids and has a predicted molecular mass of 30.8 kDa. The apparent molecular mass of the protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. TPM4 / Tropomyosin 4 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. TPM4 / Tropomyosin 4蛋白背景綜述
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells it is implicated in stabilizing cytoskeleton actin filaments. 參考文獻
Udeshi ND. et al., 2012, Mol Cell Proteomics. 11 (5): 148-59. Rostila A. et al., 2012, Lung Cancer. 77 (2): 450-9. Vlahovich N. et al., 2008, Cell Motil Cytoskeleton. 65 (1): 73-85. 規格:20ug 關 鍵 詞:TPM4 / Tropomyosin 4 Protein,技術資料,產品詳情,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
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