Cynomolgus LAMP3 / DC-LAMP Protein|廠家現貨|價格

LAMP3 / DC-LAMP蛋白產品信息

別名: LAMP3
表達方式: 
A DNA sequence encoding the cynomolgus LAMP3 (Q8MJJ2) (Lys28-Thr381) was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

LAMP3 / DC-LAMP Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Lys 28
分子量: 
The recombinant cynomolgus LAMP3 comprises 365 amino acids and has a calculated molecular mass of 39 KDa. The apparent molecular mass of it is approximately 68-105 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LAMP3 / DC-LAMP Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LAMP3 / DC-LAMP蛋白背景綜述

Dendritic cell-lysosomal associated membrane protein (DC-LAMP) /CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family. DC-LAMP and CD68 share very similar predicted structure and are the only two members of this LAMP family with a single membrane-proximal (domain II) lamp-like domain, and a region considered as a mucin-like structure rich in serines and threonines in the N-terminal portion (domain I) . DC-LAMP is highly glycosylated: the observed mass of the mature glycoprotein on SDS-PAGE is around 70–90 kDa, whereas the predicted mass for the polypeptide core is 44 kDa. The presence of DC-LAMP in the MIIC in late mature DC indicates that this may perform an important function during the processing of exogenous antigens, and might also participate in the functional remodeling of the MIIC by facilitating the translocation of MHC class II molecules to the cell surface. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

參考文獻

Bruno Salaun. et al., 2004, American Journal of Pathology. 164 (3): 861-71.
B de Saint-Vis. et al., 1998, Immunity. 9 (3): 325-36.
Hiroyuki Kanao. et al., 2005, Cancer Res. 65: (19): 8640-5.

規格：10ug

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