PGRL / IGSF8 Protein|PGRL / IGSF8蛋白質|現貨|參數

PGRL / IGSF8蛋白產品信息

別名: IGSF8, CD81P3, EWI2, KCT4
表達方式: 
A DNA sequence encoding the human IGSF8 (Q969P0-1) (Met1-Thr579) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

PGRL / IGSF8 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Arg 28
分子量: 
The recombinant human IGSF8 consists of  563 amino acids and predicts a molecular mass of  60 KDa. It migrates as an approximately 63 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PGRL / IGSF8 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PGRL / IGSF8蛋白背景綜述

Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the ***** brain.

參考文獻

Glazar AI. et al., 2009, Reprod Fertil Dev. 21 (2): 293-303.
Murdoch JN. et al., 2003, Mol Cell Neurosci. 22 (1): 62-74.
Zhang XA. et al., 2003, Cancer Res. 63 (10): 2665-74.

規格：20ug

關 鍵 詞：PGRL / IGSF8 Protein,PGRL / IGSF8蛋白質,現貨,參數，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

CANSPEC品質提供的PGRL / IGSF8 Protein|PGRL / IGSF8蛋白質|現貨|參數性能**，其優良的品質滿足您不同實驗的多種需求。

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