LILRA3 / ILT6蛋白產品信息
別名: LILRA3, ILT6, LIR4 表達方式: A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed with a polyhistidine tag at the C-terminus. 種屬: Human 表達宿主: Human Cells LILRA3 / ILT6 Protein QC Testing
純度: > 85 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Gly 24 分子量: The recombinant human LILRA3 consists of 427 amino acids and predicts a molecular mass of 46.5 KDa. It migrates as an approximately 57-66 KDa band in SDS-PAGE under reducing conditions. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. LILRA3 / ILT6 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. LILRA3 / ILT6蛋白背景綜述
ILT6 is a member of the ILT family. ILT family proteins are expressed predominantly on myeloid lineage cells, and some members have been shown to bind classical (HLA-A and -B) and non-classical (HLA-G1, -E and -F) MHC class I molecules. Several nomenclatures exist, giving each member a different ILT, LIR, LILR, CD85 or other designation. ILT6 contains 4 Ig-like C2-type (immunoglobulin-like) domains and may act as soluble receptor for class I MHC antigens. It can be detected n B-cells, and at lower levels in natural killer (NK) cells. Unlike many of its family, ILT6 lacks a transmembrane domain. If secreted, the ILT6 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. 參考文獻
Wi niewski A. et al., 2004, Hum Immunol. 64 (4): 458-61. Norman PJ. et al., 2003, Immunogenetics. 55 (3): 165-71. Cella M. et al., 1997, J Exp Med. 185 (10): 1743-51. 規格:20ug 關 鍵 詞:LILRA3 / ILT6 Protein,LILRA3 / ILT6蛋白質,價格,參數,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
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