Rat IL7R / IL7RA Protein|參數|廠家現貨

IL7R / IL7RA蛋白產品信息

別名: IL7R
表達方式: 
A DNA sequence encoding the rat IL7R (NP_001099888.1) (Met1-Asp239) was expressed with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

IL7R / IL7RA Protein QC Testing

純度: (56.5+42.6)% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 21
分子量: 
The recombinant rat IL7R comprises 230 amino acids and predicts a molecular mass of 26.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 40 and 36 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL7R / IL7RA Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL7R / IL7RA蛋白背景綜述

Interleukin 7 Receptor alpha ( IL-7Rα ), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.

參考文獻

Sudo T. et al., 1993, Proc. Natl Acad Sci. 90: 9125-9.
Park LS. et al., 2000, J Exp Med. 192: 659-70.
Pandey A. et al., 2000, Nat Immunol. 1: 59-64.
Kaech SM. et al., 2003, Nat Immunol. 4: 1191-8.
Gregory SG. et al., 2007, Nat Genet. 39 (9): 1083-91.
Mazzucchelli R. et al., 2007, Nat Rev Immunol. 7: 144-54.
Vranjkovic A. et al., 2007, Int Immunol. 19: 1329-39.

規格：50ug

關 鍵 詞：Rat IL7R / IL7RA Protein,參數,廠家現貨，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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