IL7R / IL7RA蛋白產品信息
別名: IL7R 表達方式: A DNA sequence encoding the rat IL7R (NP_001099888.1) (Met1-Asp239) was expressed with a polyhistidine tag at the C-terminus. 種屬: Rat 表達宿主: Human Cells IL7R / IL7RA Protein QC Testing
純度: (56.5+42.6)% as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Glu 21 分子量: The recombinant rat IL7R comprises 230 amino acids and predicts a molecular mass of 26.5 kDa. The apparent molecular mass of the recombinant protein is approximately 40 and 36 kDa in SDS-PAGE under reducing conditions. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. IL7R / IL7RA Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. IL7R / IL7RA蛋白背景綜述
Interleukin 7 Receptor alpha ( IL-7Rα ), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses. 參考文獻
Sudo T. et al., 1993, Proc. Natl Acad Sci. 90: 9125-9. Park LS. et al., 2000, J Exp Med. 192: 659-70. Pandey A. et al., 2000, Nat Immunol. 1: 59-64. Kaech SM. et al., 2003, Nat Immunol. 4: 1191-8. Gregory SG. et al., 2007, Nat Genet. 39 (9): 1083-91. Mazzucchelli R. et al., 2007, Nat Rev Immunol. 7: 144-54. Vranjkovic A. et al., 2007, Int Immunol. 19: 1329-39. 規格:50ug 關 鍵 詞:Rat IL7R / IL7RA Protein,參數,廠家現貨,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
CANSPEC品質提供的Rat IL7R / IL7RA Protein|參數|廠家現貨性能**,其優良的品質滿足您不同實驗的多種需求。
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